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Name:L685458
Catalog No.:B0011
Structure:
Chemical Properties Cas No.:292632-98-5 Purity Limit: Synonyms: Molecular Weight:672.39 Formula:C39H52N4O6 Storage: Solubility:
Shipping Condition
Quality Control & MSDS
Description L685458 is a potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro
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