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Name:RC-100
Catalog No.:A0027
Structure:
Chemical Properties Cas No.:724760-19-4 Purity Limit: Synonyms:Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg) (Disulfide bonds between Cys3 and Cys1 /Cys and Cys1 /Cys and Cys12) Trifluoroacetate salt Molecular Weight:1918.42 Formula:C74H128N30O18S6 Storage: Solubility:
Shipping Condition
Quality Control & MSDS
Description The theta-defensin retrocyclin-1, also called RC-100, is a circular octadecapeptide containing an internal trisulfide ladder. Besides its antimicrobial activity, retrocyclin-1 has a remarkable ability to protect human cells in vitro from infection by T- and M-tropic strains of HIV-1. Its effectiveness against HIV-1 results from the prevention of viral entry, and is correlated with its ability to recognize and bind with high affinity to glycoproteins and glycolipids implicated in HIV-1 entry, such as gp120 (KD = 35.4 nM), CD4 (KD = 31 nM), and galactosylceramide (KD = 24.1 nM). Retrocyclin represents a new class of small molecule HIV-1 entry inhibitors
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